Prevalence of K-RAS and P53 Mutation in Periampullary Carcinoma and Its Impact on the Pathological Staging at a Tertiary Referral Hospital in Chennai

This present study has observed that 1. A high prevalence of K-ras and P53 mutation in periampullary carcinoma in the regional population. More samples were positive for K-ras mutation than P53 mutation(Many studies has shown increased p53 mutation than K-ras mutation ,especially in pancreas carcinoma). 2. The mutation status has not affected the variables such as Age, Gender, nodal metastasis, lympho-vascular/neural invasion and grade of the tumor. 3. By logistic regression analysis, the Odds of occurrence of mutation was 12.3 times due to size and 1.4 times due to distant metastasis. 4. Nearly half of the mutated cases were less than T2 lesions indicating that K-ras and p-53 mutations occur early in carcinogenesis process of periampullary carcinoma. 5. Whether this mutation status in periampullary carcinoma affects the longterm survival(as in various other studies) has to be seen in the follow-up studies in future. 6. A study with a larger sample size will give a clear understanding about these facts in our regional population. 7. Though K-ras mutation commonly occurs in codon 12 and codon 13, future genetic studies may concentrate on mutation in other codons and also different types of mutation like DPC4, APC, Beta Catenine pathway etc., 8. Future studies involving the gene expression pathways may open avenues in different genes that gets mutated in periampullary carcinoma. 9. Better understanding of the molecular biology of periampullary carcinoma is of interest, not only in basic research but will have clinical implications in assessing risk of developing periampullary cancers,its early diagnosis, treatment and for prognosis

Compositional analysis of the very-low-Ti mare basalt component of NWA 773 and comparison with low-Ti basalts, LAP03632 and LAP02436

Abstract not available

Anatomical information science

The Foundational Model of Anatomy (FMA) is a map of the human body. Like maps of other sorts – including the map-like representations we find in familiar anatomical atlases – it is a representation of a certain portion of spatial reality as it exists at a certain (idealized) instant of time. But unlike other maps, the FMA comes in the form of a sophisticated ontology of its objectdomain, comprising some 1.5 million statements of anatomical relations among some 70,000 anatomical kinds. It is further distinguished from other maps in that it represents not some specific portion of spatial reality (say: Leeds in 1996), but rather the generalized or idealized spatial reality associated with a generalized or idealized human being at some generalized or idealized instant of time. It will be our concern in what follows to outline the approach to ontology that is represented by the FMA and to argue that it can serve as the basis for a new type of anatomical information science. We also draw some implications for our understanding of spatial reasoning and spatial ontologies in general

Effect of Ni-doping on magnetism and superconductivity in Eu0.5K0.5Fe2As2

The effect of Ni-doping on the magnetism and superconductivity in Eu0.5K0.5Fe2As2 has been studied through a systematic investigation of magnetic and superconducting properties of Eu0.5K0.5(Fe1-xNix)2As2 (x = 0, 0.03, 0.05, 0.08 and 0.12) compounds by means of dc and ac magnetic susceptibilities, electrical resistivity and specific heat measurements. Eu0.5K0.5Fe2As2 is known to exhibit superconductivity with superconducting transition temperature Tc as high as 33 K. The Ni-doping leads to a rapid decrease in Tc; Tc is reduced to 23 K with 3% Ni-doping, and 8% Ni-doping suppresses the superconductivity to below 1.8 K. In 3% Ni-doped sample Eu0.5K0.5(Fe0.97Ni0.03)2As2 superconductivity coexists with short range ordering of Eu2+ magnetic moments at Tm ~ 6 K. The suppression of superconductivity with Ni-doping is accompanied with the emergence of a long range antiferromagnetic ordering with TN = 8.5 K and 7 K for Eu0.5K0.5(Fe0.92Ni0.08)2As2 and Eu0.5K0.5(Fe0.88Ni0.12)2As2, respectively. The temperature and field dependent magnetic measurements for x = 0.08 and 0.12 samples reflect the possibility of a helical magnetic ordering of Eu2 moments. We suspect that the helimagnetism of Eu spins could be responsible for the destruction of superconductivity as has been observed in Co-doped EuFe2As2. The most striking feature seen in the resistivity data for x = 0.08 is the reappearance of the anomaly presumably due to spin density wave transition at around 60 K. This could be attributed to the compensation of holes (K-doping at Eu-site) by the electrons (Ni-doping at Fe site). The anomaly associated with spin density wave further shifts to 200 K for x = 0.12 for which the electron doping has almost compensated the holes in the system.Comment: 9 pages, 10 figure

University Spaces as Agents of National Belonging: Analysing the Visual Culture of Public Universities’ Campuses in India and Pakistan

This article discusses the role of ‘space’ in Indian and Pakistani public sector universities in fostering national pride. University spaces have been highlighted, in both countries, for being used by the governments as agents fostering the national narrative yet there is limited research on how these spaces contribute to the visual culture of educational institutions and in the inculcation of nationalistic values. This article adds to the conversations regarding the fostering of national belonging and pride in universities by exploring space as a constitutive element of the visual culture of the higher education environment in India and Pakistan. In both countries, the physical spaces of public universities have become platforms for channelling student voices. This research uses two state-funded universities, from Delhi (in India) and Lahore (in Pakistan), and Lefebvre’s conception of space to conduct a discourse analysis of bulletin boards, graffiti, statues, sculptures, and any other imagery found online pertaining to the campuses and analyse how it is a ‘conceived’ and ‘perceived’ aspect of the visual culture of the universities. It adds to current scholarly conversations on national pride and consciousness in India and Pakistan by showing how university spaces can potentially play an active role in promoting the state’s narrative in students’ or educators’ everyday educational experiences

Supersensitive measurement of angular displacements using entangled photons

We show that the use of entangled photons having non-zero orbital angular momentum (OAM) increases the resolution and sensitivity of angular-displacement measurements performed using an interferometer. By employing a 4$\times$4 matrix formulation to study the propagation of entangled OAM modes, we analyze measurement schemes for two and four entangled photons and obtain explicit expressions for the resolution and sensitivity in these schemes. We find that the resolution of angular-displacement measurements scales as $Nl$ while the angular sensitivity increases as $1/(2Nl)$, where $N$ is the number of entangled photons and $l$ the magnitude of the orbital-angular-momentum mode index. These results are an improvement over what could be obtained with $N$ non-entangled photons carrying an orbital angular momentum of $l\hbar$ per photonComment: 6 pages, 3 figure

The Mortgage Crisis: Government Intervention And Debtors Options

The real estate market crash was a major contributor in creating the dismal global economic situation. The paper reviews the options of the homeowners in debt and the government’s actions to stimulate the real estate market